Vitamin B12 Deficiency and Metformin Use
Vitamin B12 (cobalamin) is a
water-soluble vitamin obtained essentially from animal sources such as meat and
fish. Deficiency of Vitamin B12 causes anemia. It is a vital cofactor in the
conversion of homocysteine to methionine and recovery of folate. This is an
important step in the metabolic procedure that leads to DNA synthesis and
formation and protection of the myelin sheath. Metformin is a medication
utilized for the treatment of diabetes. Metformin increases insulin sensitivity
in the liver and decreases glucose generation. It is also used to treat
polycystic ovarian disorder, an ailment linked to high blood glucose levels.
Metformin is presently concentrated on as a treatment for heart attack
recovery, tuberculosis and cancer prevention.
By
Chandrasekharan
III B.Sc
Department of Biochemistry
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